Publications

Glitches in the brain: the dangerous relationship between radiotherapy and brain fog

Marino N, Bedeschi M, Vaccari ME, Cambiaghi M, Tesei A

Front Cell Neurosci. 2024;18:1328361. Published 2024 Mar 7. doi:10.3389/fncel.2024.1328361

Melatonin MT1 receptors as a target for the psychopharmacology of bipolar disorder: A translational study

Tassan Mazzocco M, Pisanu C, Russo L, Acconcia C, Cambiaghi M, De Girolamo S, Squassina A, Cherchi L, Monzani E, Scebba F, Angeloni D, De Gregorio D, Nasini S, Dall'Acqua S, Sut S, Suprani F, Garzilli M, Guiso B, Pulcinelli V, Iaselli MN, Pinna I, Somaini G, Arru L, Corrias C, Paribello P, Pinna F, Gobbi G, Valtorta F, Carpiniello B, Manchia M, Comai S.

Pharmacol Res. 2023;198:106993. doi:10.1016/j.phrs.2023.106993

Pre- and postsynaptic N-methyl-D-aspartate receptors are required for sequential printing of fear memory engrams

Bertocchi I, Rocha-Almeida F, Romero-Barragán MT, Cambiaghi M, Carretero-Guillén A, Botta P, Dogbevia GK, Treviño M, Mele P, Oberto A, Larkum ME, Gruart A, Sprengel R, Delgado-García JM, Hasan MT

iScience. 2023;26(11):108050. Published 2023 Sep 25. doi:10.1016/j.isci.2023.108050

Age-Related Effects of Exogenous Melatonin on Anxiety-like Behavior in C57/B6J Mice

Nasini S, Tidei S, Shkodra A, De Gregorio D, Cambiaghi M, Comai S.

Biomedicines. 2023;11(6):1705. Published 2023 Jun 13. doi:10.3390/biomedicines11061705

Integrative transcriptomic and metabolic analyses of the mammalian hibernating brain identifies a key role for succinate dehydrogenase in ischemic tolerance. 

Bernstock JD, Willis CM, Garcia-Segura ME, Gaude E, Anni D, Lee YJ, Thomas LW, Casey A, Vicario N, Leonardi T, Nicaise AM, Gessler FA, Izzy S, Buffelli MR, Seidlitz J, Srinivasan S, Murphy MP, Ashcroft M, Cambiaghi M, Hallenbeck JM, Peruzzotti-Jametti L.

Preprint. bioRxiv. 2023;2023.03.29.534718. Published 2023 Mar 30. doi:10.1101/2023.03.29.534718

Advances toward precision therapeutics for developmental and epileptic encephalopathies 

Bertocchi I, Cambiaghi M, Hasan MT. 

Front Neurosci. 2023 Apr 6;17:1140679. doi: 10.3389/fnins.2023.1140679. PMID: 37090807; PMCID: PMC10115946.

Ten-year follow-up of auditory brainstem implants: From intra-operative electrical auditory brainstem responses to perceptual results 

Veronese S, Cambiaghi M, Tommasi N, Sbarbati A, Galvin JJ 3rd. 

PLoS One. 2023 Mar 2;18(3):e0282261. doi: 10.1371/journal.pone.0282261. PMID: 36862753; PMCID: PMC9980821.

Editorial: Non-invasive brain stimulation techniques in neurological and neuropsychiatric disorders: Physiological and molecular evidence

Cambiaghi M, Cordaro M, Dossena S, Cuzzocrea S, Buffelli M. 

Front Syst Neurosci. 2023 Feb 6;17:1128205. doi: 10.3389/fnsys.2023.1128205. PMID: 36814991; PMCID: PMC9939818.

In vivo morphological alterations of TAMs during KCa3.1 inhibition-by using in vivo two-photon time-lapse technology

Massenzio F, Cambiaghi M, Marchiotto F, Boriero D, Limatola C, D'Alessandro G, Buffelli M. 

Front Cell Neurosci. 2022 Dec 15;16:1002487. doi: 10.3389/fncel.2022.1002487. PMID: 36589283; PMCID: PMC9798303.

High-frequency rTMS modulates emotional behaviors and structural plasticity in layers II/III and V of the mPFC 

Cambiaghi M, Infortuna C, Gualano F, Elsamadisi A, Malik W, Buffelli M, Han Z, Solhkhah R, P Thomas F, Battaglia F. 

Front Cell Neurosci. 2022 Dec 13;16:1082211. doi: 10.3389/fncel.2022.1082211. PMID: 36582213; PMCID: PMC9792489.

Neural precursor cells tune striatal connectivity through the release of IGFBPL1

Butti E, Cattaneo S, Bacigaluppi M, Cambiaghi M, Scotti GM, Brambilla E, Ruffini F, Sferruzza G, Ripamonti M, Simeoni F, Cacciaguerra L, Zanghì A, Quattrini A, Fesce R, Panina-Bordignon P, Giannese F, Cittaro D, Kuhlmann T, D'Adamo P, Rocca MA, Taverna S, Martino G. 

Nat Commun. 2022 Dec 8;13(1):7579. doi: 10.1038/s41467-022-35341-y. PMID: 36482070; PMCID: PMC9731988.

Photothrombotic Mouse Models for the Study of Melatonin as a Therapeutic Tool After Ischemic Stroke

Cambiaghi M, Cherchi L, Comai S. 

Methods Mol Biol. 2022;2550:433-441. doi: 10.1007/978-1-0716-2593-4_42. PMID: 36180711.

Early Application of Ipsilateral Cathodal-tDCS in a Mouse Model of Brain Ischemia Results in Functional Improvement and Perilesional Microglia Modulation 

Cherchi L, Anni D, Buffelli M, Cambiaghi M. 

Biomolecules. 2022 Apr 17;12(4):588. doi: 10.3390/biom12040588. PMID: 35454177; PMCID: PMC9027610.

High-frequency repetitive transcranial magnetic stimulation enhances layer II/III morphological dendritic plasticity in mouse primary motor cortex

Cambiaghi M, Cherchi L, Masin L, Infortuna C, Briski N, Caviasco C, Hazaveh S, Han Z, Buffelli M, Battaglia F. 

Behav Brain Res. 2021 Jul 23;410:113352. doi: 10.1016/j.bbr.2021.113352. Epub 2021 May 9. PMID: 33979657.

The Effects of 1-Hz rTMS on Emotional Behavior and Dendritic Complexity of Mature and Newly Generated Dentate Gyrus Neurons in Male Mice 

Cambiaghi M, Crupi R, Bautista EL, Elsamadisi A, Malik W, Pozdniakova H, Han Z, Buffelli M, Battaglia F. 

Int J Environ Res Public Health. 2020 Jun 8;17(11):4074. doi: 10.3390/ijerph17114074. PMID: 32521613; PMCID: PMC7312937.

Transcranial direct current stimulation of the mouse prefrontal cortex modulates serotonergic neural activity of the dorsal raphe nucleus

Cambiaghi M, Buffelli M, Masin L, Valtorta F, Comai S. 

Brain Stimul. 2020 May-Jun;13(3):548-550. doi: 10.1016/j.brs.2020.01.012. Epub 2020 Jan 17. PMID: 32289674.

Coherent Activity between the Prelimbic and Auditory Cortex in the Slow-Gamma Band Underlies Fear Discrimination

Concina G, Cambiaghi M, Renna A, Sacchetti B. 

J Neurosci. 2018 Sep 26;38(39):8313-8328. doi: 10.1523/JNEUROSCI.0540-18.2018. Epub 2018 Aug 9. PMID: 30093537; PMCID: PMC6596172.

Reversible Inactivation of the Higher Order Auditory Cortex during Fear Memory Consolidation Prevents Memory-Related Activity in the Basolateral Amygdala during Remote Memory Retrieval

Cambiaghi M, Renna A, Milano L, Sacchetti B. 

Front Behav Neurosci. 2017 Jul 25;11:138. doi: 10.3389/fnbeh.2017.00138. PMID: 28790901; PMCID: PMC5524669.

Severe Intellectual Disability and Enhanced Gamma-Aminobutyric Acidergic Synaptogenesis in a Novel Model of Rare RASopathies

Papale A, d'Isa R, Menna E, Cerovic M, Solari N, Hardingham N, Cambiaghi M, Cursi M, Barbacid M, Leocani L, Fasano S, Matteoli M, Brambilla R. 

Biol Psychiatry. 2017 Feb 1;81(3):179-192. doi: 10.1016/j.biopsych.2016.06.016. Epub 2016 Jun 27. PMID: 27587266.

Differential Recruitment of Auditory Cortices in the Consolidation of Recent Auditory Fearful Memories

Cambiaghi M, Grosso A, Renna A, Sacchetti B. 

J Neurosci. 2016 Aug 17;36(33):8586-97. doi: 10.1523/JNEUROSCI.0561-16.2016. PMID: 27535907; PMCID: PMC6601899.

Region- and Layer-Specific Activation of the Higher Order Auditory Cortex Te2 after Remote Retrieval of Fear or Appetitive Memories

Grosso A, Cambiaghi M, Milano L, Renna A, Sacco T, Sacchetti B. 

Cereb Cortex. 2017 Jun 1;27(6):3140-3151. doi: 10.1093/cercor/bhw159. PMID: 27252348.

Higher-Order Sensory Cortex Drives Basolateral Amygdala Activity during the Recall of Remote, but Not Recently Learned Fearful Memories

Cambiaghi M, Grosso A, Likhtik E, Mazziotti R, Concina G, Renna A, Sacco T, Gordon JA, Sacchetti B. 

J Neurosci. 2016 Feb 3;36(5):1647-59. doi: 10.1523/JNEUROSCI.2351-15.2016. PMID: 26843646; PMCID: PMC6601987.

The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli

Grosso A, Cambiaghi M, Renna A, Milano L, Roberto Merlo G, Sacco T, Sacchetti B. 

Nat Commun. 2015 Dec 1;6:8886. doi: 10.1038/ncomms9886. PMID: 26619940; PMCID: PMC5482717.

Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks

Pennucci R, Talpo F, Astro V, Montinaro V, Morè L, Cursi M, Castoldi V, Chiaretti S, Bianchi V, Marenna S, Cambiaghi M, Tonoli D, Leocani L, Biella G, D'Adamo P, de Curtis I. 

Cereb Cortex. 2016 Feb;26(2):873-890. doi: 10.1093/cercor/bhv274. Epub 2015 Nov 17. PMID: 26582364; PMCID: PMC4712809.

Acute administration of nicotine into the higher order auditory Te2 cortex specifically decreases the fear-related charge of remote emotional memories 

Cambiaghi M, Grosso A, Renna A, Concina G, Sacchetti B. 

Neuropharmacology. 2015 Dec;99:577-88. doi: 10.1016/j.neuropharm.2015.08.036. Epub 2015 Aug 28. PMID: 26319210; PMCID: PMC4710760.

Importance of EEG in validating the chronic effects of drugs: suggestions from animal models of epilepsy treated with rapamycin

Cambiaghi M, Magri L, Cursi M. 

Seizure. 2015 Apr;27:30-9. doi: 10.1016/j.seizure.2015.02.015. Epub 2015 Feb 24. PMID: 25891924.

Safety and efficacy of transcranial direct current stimulation in acute experimental ischemic stroke

Peruzzotti-Jametti L, Cambiaghi M, Bacigaluppi M, Gallizioli M, Gaude E, Mari S, Sandrone S, Cursi M, Teneud L, Comi G, Musco G, Martino G, Leocani L. 

Stroke. 2013 Nov;44(11):3166-74. doi: 10.1161/STROKEAHA.113.001687. Epub 2013 Aug 27. PMID: 23982710.

Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models

Magri L, Cominelli M, Cambiaghi M, Cursi M, Leocani L, Minicucci F, Poliani PL, Galli R. 

Dis Model Mech. 2013 Sep;6(5):1185-97. doi: 10.1242/dmm.012096. Epub 2013 Jun 5. PMID: 23744272; PMCID: PMC3759338.

Emerging subspecialties in Neurology: transcranial stimulation

Peruzzotti-Jametti L, Bacigaluppi M, Sandrone S, Cambiaghi M. 

Neurology. 2013 Jan 22;80(4):e33-5. doi: 10.1212/WNL.0b013e3182833d74. PMID: 23339212.

Behavioural and EEG effects of chronic rapamycin treatment in a mouse model of tuberous sclerosis complex

Cambiaghi M, Cursi M, Magri L, Castoldi V, Comi G, Minicucci F, Galli R, Leocani L. 

Neuropharmacology. 2013 Apr;67:1-7. doi: 10.1016/j.neuropharm.2012.11.003. Epub 2012 Nov 14. PMID: 23159330.

Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity

Butti E, Bacigaluppi M, Rossi S, Cambiaghi M, Bari M, Cebrian Silla A, Brambilla E, Musella A, De Ceglia R, Teneud L, De Chiara V, D'Adamo P, Garcia-Verdugo JM, Comi G, Muzio L, Quattrini A, Leocani L, Maccarrone M, Centonze D, Martino G. 

Brain. 2012 Nov;135(Pt 11):3320-35. doi: 10.1093/brain/aws194. Epub 2012 Sep 24. PMID: 23008234.

Temporal evolution of neurophysiological and behavioral features of synapsin I/II/III triple knock-out mice

Cambiaghi M, Cursi M, Monzani E, Benfenati F, Comi G, Minicucci F, Valtorta F, Leocani L. 

Epilepsy Res. 2013 Feb;103(2-3):153-60. doi: 10.1016/j.eplepsyres.2012.07.012. Epub 2012 Jul 28. PMID: 22846639; PMCID: PMC3574234.

n-3 fatty acids prevent impairment of neurogenesis and synaptic plasticity in B-cell activating factor (BAFF) transgenic mice

Crupi R, Cambiaghi M, Deckelbaum R, Hansen I, Mindes J, Spina E, Battaglia F. 

Prev Med. 2012 May;54 Suppl:S103-8. doi: 10.1016/j.ypmed.2011.12.019. Epub 2011 Dec 28. PMID: 22227286.

Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions

Magri L, Cambiaghi M, Cominelli M, Alfaro-Cervello C, Cursi M, Pala M, Bulfone A, Garcìa-Verdugo JM, Leocani L, Minicucci F, Poliani PL, Galli R. 

Cell Stem Cell. 2011 Nov 4;9(5):447-62. doi: 10.1016/j.stem.2011.09.008. PMID: 22056141.

Reduced adult neurogenesis and altered emotional behaviors in autoimmune-prone B-cell activating factor transgenic mice

Crupi R, Cambiaghi M, Spatz L, Hen R, Thorn M, Friedman E, Vita G, Battaglia F. 

Biol Psychiatry. 2010 Mar 15;67(6):558-66. doi: 10.1016/j.biopsych.2009.12.008. PMID: 20185032.

Brain transcranial direct current stimulation modulates motor excitability in mice

Cambiaghi M, Velikova S, Gonzalez-Rosa JJ, Cursi M, Comi G, Leocani L. 

Eur J Neurosci. 2010 Feb;31(4):704-9. doi: 10.1111/j.1460-9568.2010.07092.x. Epub 2010 Feb 5. PMID: 20141528.